What is tamsulosin?
Tamsulosin is selective and competitive antagonist of postsynaptic α1A-adrenergic receptors. Tamsulosin reduces smooth muscle tone in the prostate and urethra. It increases the maximum urinary flow rate, relieve the symptoms and stagnation. Reduction of symptoms associated with filling and emptying of the bladder is maintained during long-term therapy. The drug is rapidly absorbed from the gastrointestinal tract, bioavailability is almost complete, reduces the absorption of food. After a single dose maximum plasma concentration occurs after about 6 h Steady state is achieved after approximately 5 days of taking the drug. Tamsulosin binds to plasma proteins is approximately 99%. Is metabolised in the liver and excreted primarily in the urine, 9% of the dose - unchanged. T0, 5 in the adoption of the single product after the meal is about 10 h in the steady state of approximately 13 hr
The symptoms related to lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia.
1 capsule contains sustained release of tamsulosin hydrochloride 0.4 mg. The product contains sucrose, sunset yellow and azorubine.
The drug is intended for use in men.
Toxicity of tamsulosin after a single dose and with repeated dosing has been studied in mice, rats and dogs. Reproductive toxicity has also been studied in rats, carcinogenicity in mice and rats, and genotoxicity in vivo and in vitro. The general profile of tamsulosin toxicity at high doses is equivalent to the action of pharmacological antagonists of alpha-adrenergic receptors. In dogs tamsulosin administered in very high doses cause changes in the ECG. I do not believe, however, that that would be of clinical relevance. Showed no significant genotoxic properties of tamsulosin use.
Tamsulosin for kidney stones
Interesting and useful in terms of daily urological practice is the observation on the impact of tamsulosin contractility of the muscle membrane of the ureter, which is important in the treatment ureterolithiasis and facilitating the excretion of urinary deposits, eg. After surgery crushing kidney stones endoscopic or ESWL. Contractility were investigated an ureter wall fragments in the presence of various concentrations of tamsulosin, phenylephrine and norepinephrine.
Hypersensitivity to tamsulosin hydrochloride or any of the excipients, including angioedema caused by the drug. Orthostatic hypotension in an interview. Severe hepatic impairment.
Due to the lack of clinical trials used with caution in patients with severe renal impairment (creatinine clearance <10 mL / min). Use caution in patients with significant hepatic impairment. It is not recommended to initiate treatment with tamsulosin in patients for whom surgical treatment is planned cataract surgery (risk of intraoperative Floppy Iris team - IFIS - during cataract surgery). The product contains sucrose - it should not be administered to patients with rare hereditary problems of fructose intolerance, malabsorption glucose-galactose malabsorption or sucrase-isomaltase. Included in the preparation sunset yellow and azorubine may cause allergic reactions.
Tamsulosin Side effects
Common: dizziness, abnormal ejaculation. Uncommon: headache, palpitations, orthostatic hypotension, rhinitis, constipation, diarrhea, nausea, vomiting, rash, pruritus, urticaria, asthenia. Rare: syncope, angioedema. Very rare: Stevens-Johnson syndrome, priapism.
Oral. Adults: 1 capsule a day, after breakfast or the first meal of the day. The capsules should be swallowed whole.
Tamsulosin ER (extended-release) is marketed as Flomax. The capsule contains 0.4 mg of tamsulosin hcl.